RAF Typhoon FGR4s have operated alongside French aircraft in a joint strike targeting an underground arms cache in Syrian territory used by the IS group, per a report from the UK Ministry of Defence.
The location, pinpointed through intelligence, was believed to be containing munitions and bombs, the release indicated, and was situated in mountainous terrain just above the ancient city of Palmyra in Syria's central region.
"Our fighter planes utilized laser-guided Paveway IV weapons to strike a series of approach shafts leading to the facility... early reports are that the target was engaged successfully," officials stated.
There was no evidence of any civilian casualties in the attack conducted Saturday night and each participating jet returned to base without incident, the ministry further stated.
The British jets were backed up by a Voyager tanker plane.
Daesh - also known as Daesh - imposed militant control over large swathes of both Syria and Iraq prior to its 2019 collapse.
"This action shows the UK's leading role, and determination to operate in unison with allied nations, to stamp out any resurgence of IS and their violent and radical beliefs in the Middle East," the British Defence Secretary John Healey said.
RAF aircraft have carried out patrols over Syria to "deter any attempted comeback" of the group following its military defeat at the battle of Baghuz in 2019, the authorities noted.
"I extend gratitude to all the members of British forces who took part in this mission for their expertise and their valour," he commented. "They were part of thousands of British troops stationed over the holidays. This action, to eliminate dangerous terrorists who threaten our safety, highlights how UK forces are ready to step up, continuously, protecting the UK within its borders and powerful internationally."
In December, the United States armed forces carried out what it termed a "large-scale strike" on IS targets in Syria, after an assault claimed the lives of two American soldiers and a civilian interpreter in Palmyra.
The UN says Islamic State still boasts an estimated 5,000 to 7,000 militants in both countries.